Title : The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation.

Pub. Date : 2015 Jul

PMID : 25758096






1 Functional Relationships(s)
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1 In U937 cells, rapamycin alone increased the activity of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and the addition of ATO decreased the level of phosphorylated ERK, Ser473 phosphorylated Akt and anti-apoptotic Mcl-1 protein. Arsenic Trioxide MCL1 apoptosis regulator, BCL2 family member Homo sapiens