Title : Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways.

Pub. Date : 2015 Jun

PMID : 25752913






1 Functional Relationships(s)
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1 In the rat rotenone model of Parkinson"s disease (PD), striatal RAGE/NFkappaB signaling was up-regulated associated with elevated levels of inflammatory, oxidative stress, and apoptotic mediators resulting in dopaminergic neurons death and hence motor impairment. Rotenone advanced glycosylation end product-specific receptor Rattus norvegicus