Protein Name advanced glycosylation end product-specific receptor
Organism Rattus norvegicus
Gene ID 81722
Gene Symbol

Ager

UniProt Q6MG86 (Q6MG86_RAT), A0A0G2K218 (A0A0G2K218_RAT)
Relationships Total Number of functionally related compound(s) : 248
Total Number of Articles : 269
Description

advanced glycosylation end product-specific receptor

Gene Summary

Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of cell migration; and response to hexose. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including bone disease (multiple); cardiovascular system disease (multiple); colorectal carcinoma; diabetic encephalopathy; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • advanced glycosylation end product-specific receptor
  • receptor for advanced glycosylation end products
  • RAGE
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Properties