| Protein Name | advanced glycosylation end product-specific receptor |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 81722 |
| Gene Symbol | Ager |
| UniProt | Q6MG86 (Q6MG86_RAT), A0A0G2K218 (A0A0G2K218_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
248
Total Number of Articles : 269 |
Description |
advanced glycosylation end product-specific receptor |
| Gene Summary |
Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; positive regulation of metabolic process; and regulation of cell migration. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including alcohol use disorder; bone disease (multiple); cardiovascular system disease (multiple); gastrointestinal system disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |