Title : Calcium sensing receptor mediated the excessive generation of β-amyloid peptide induced by hypoxia in vivo and in vitro.

Pub. Date : 2015 Apr 17

PMID : 25747709






1 Functional Relationships(s)
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1 Hypoxia or GdCl3, an agonist of CaSR, increased the expression of BACE1 in hippocampal neurons and tissue, but Calhex 231 or Xesto C (a selective inhibitor of IP3 receptor) partly prevented hypoxia-induced BACE1 overexpression. gadolinium chloride inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens