Title : NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required.

Pub. Date : 2015 Mar 6

PMID : 25746394






2 Functional Relationships(s)
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1 NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required. Morphine glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus
2 CONCLUSIONS: Arc/Arg3.1 in the NAc shell mediates the reconsolidation of morphine-associated context memory via up-regulating the level of membrane of GluR1, for which the local activation of the ERK-CREB signal pathway, as an upstream mechanism of Arc/Arg3.1, is required. Morphine glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus