Pub. Date : 2015
PMID : 25745356
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Administration of morphine alone resulted in significantly increased expression of PKCgamma and NR1 proteins in the spinal cord. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 2 | These increased levels of expression of PKCgamma and NR1 were significantly inhibited by co-administration of morphine with melatonin. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 3 | CONCLUSIONS: Our findings demonstrate that melatonin have potential to attenuate repetitive morphine-induced hyperalgesia and tolerance, possibly by inhibiting PKCgamma and NR1 activities in the spinal cord. | Morphine | protein kinase C, gamma | Rattus norvegicus |