Pub. Date : 2015 May 1
PMID : 25744718
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By selective inhibition of CDK4/CDK6 with PD 0332991, which leads to early G1 arrest and synchronous S-phase entry upon release of the G1 block, we have developed a novel strategy to prime acute myeloid leukemia (AML) cells for cytotoxic killing by cytarabine (Ara-C). | Cytarabine | cyclin dependent kinase 6 | Homo sapiens |
| 2 | By selective inhibition of CDK4/CDK6 with PD 0332991, which leads to early G1 arrest and synchronous S-phase entry upon release of the G1 block, we have developed a novel strategy to prime acute myeloid leukemia (AML) cells for cytotoxic killing by cytarabine (Ara-C). | Cytarabine | cyclin dependent kinase 6 | Homo sapiens |
| 3 | In vivo, timely inhibition of CDK4/CDK6 by PD 0332991 and release profoundly suppresses tumor growth in response to reduced doses of Ara-C in a xenograft AML model. | Cytarabine | cyclin dependent kinase 6 | Homo sapiens |
| 4 | Collectively, these data suggest selective and reversible inhibition of CDK4/CDK6 as an effective means to enhance Ara-C killing of AML cells at reduced doses, which has implications for the treatment of elderly AML patients who are unable to tolerate high-dose Ara-C therapy. | Cytarabine | cyclin dependent kinase 6 | Homo sapiens |
| 5 | Collectively, these data suggest selective and reversible inhibition of CDK4/CDK6 as an effective means to enhance Ara-C killing of AML cells at reduced doses, which has implications for the treatment of elderly AML patients who are unable to tolerate high-dose Ara-C therapy. | Cytarabine | cyclin dependent kinase 6 | Homo sapiens |