Title : Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity.

Pub. Date : 2015 May 15

PMID : 25742316






2 Functional Relationships(s)
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1 Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity. Salicylates insulin Homo sapiens
2 We find doses of metformin and salicylate used clinically synergistically activate AMPK in vitro and in vivo, resulting in reduced liver lipogenesis, lower liver lipid levels and improved insulin sensitivity in mice. Salicylates insulin Homo sapiens