Title : Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1α signaling pathways in human retinal pigment epithelial cells under hypoxic conditions.

Pub. Date : 2015 May

PMID : 25738890






3 Functional Relationships(s)
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1 Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1alpha signaling pathways in human retinal pigment epithelial cells under hypoxic conditions. caffeic acid phenethyl ester hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Pre-treatment with CAPE suppressed the hypoxia-induced production of VEGF in the ARPE-19 cells, and this effect was inhibited through the attenuation of reactive oxygen species (ROS) production, and the inhibition of phosphoinositide 3-kinase (PI3K)/AKT and hypoxia-inducible factor-1alpha (HIF-1alpha) expression. caffeic acid phenethyl ester hypoxia inducible factor 1 subunit alpha Homo sapiens
3 Pre-treatment with CAPE suppressed the hypoxia-induced production of VEGF in the ARPE-19 cells, and this effect was inhibited through the attenuation of reactive oxygen species (ROS) production, and the inhibition of phosphoinositide 3-kinase (PI3K)/AKT and hypoxia-inducible factor-1alpha (HIF-1alpha) expression. caffeic acid phenethyl ester hypoxia inducible factor 1 subunit alpha Homo sapiens