Pub. Date : 2015 May
PMID : 25738706
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the present study was to demonstrate that ribavirin, a known inhibitor of eIF4E and inosine 5"-phosphate dehydrogenase (IMPDH), also inhibits histone methyltransferase zeste homolog 2 (EZH2). | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |
| 2 | Ribavirin induced variable growth inhibition in a number of cell lines and downregulation of the targets, EZH2, eIF4E and IMPDH1 and 2 by siRNA led to comparable growth inhibition while no significant further reduction in viability was observed when siRNA transfected cells were treated with ribavirin. | Ribavirin | eukaryotic translation initiation factor 4E | Homo sapiens |