Pub. Date : 2015 Mar 3
PMID : 25730880
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK. | ibrutinib | Bruton agammaglobulinemia tyrosine kinase | Mus musculus |
| 2 | Ibrutinib, an approved therapy for B-cell malignancies, is a covalent inhibitor of BTK, a member of the B-cell receptor (BCR) signaling pathway, which is critical to the survival of malignant B cells. | ibrutinib | Bruton agammaglobulinemia tyrosine kinase | Mus musculus |
| 3 | These preclinical results suggest that the combination of PD1/PD1-L blockade and ibrutinib should be tested in the clinic for the therapy not only of lymphoma but also in other hematologic malignancies and solid tumors that do not even express BTK. | ibrutinib | Bruton agammaglobulinemia tyrosine kinase | Mus musculus |