PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25727020-5 2015 omega-3FFA and tamoxifen significantly increased Erk1/2 and Akt phosphorylation levels in a dose and time dependent manner. Tamoxifen 15-24 AKT serine/threonine kinase 1 Homo sapiens 60-63 25727020-6 2015 Compared to omega-3FFA alone, the combination of tamoxifen with omega-3FFA significantly increased Erk1/2 and Akt phosphorylation levels. Tamoxifen 49-58 AKT serine/threonine kinase 1 Homo sapiens 110-113 25727020-7 2015 Because Erk1/2 and Akt activation has been linked to tamoxifen-related anti-estrogen resistance in breast cancer patients, these results indicate that omega-3FFA may interfere with the effects of tamoxifen in the prevention of breast cancer risk. Tamoxifen 53-62 AKT serine/threonine kinase 1 Homo sapiens 19-22