Title : Tocopherol isoforms (α-, γ-, and δ-) show distinct capacities to control Nrf-2 and NfκB signaling pathways that modulate inflammatory response in Caco-2 intestinal cells.

Pub. Date : 2015 Jun

PMID : 25724683






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we aim to investigate the relative capacity of Toc isoforms to modify the stress-activated NfkappaB and Nrf-2 signaling pathways that regulate the expression of pro-inflammatory cytokines and antioxidant enzymes, respectively, in this well-established in vitro model of the small intestine The modulation of IFNgamma/phorbol myristate acetate (PMA)-induced inflammatory responses, determined by the expression of IL8 mRNA and protein, corresponded to the extent by which different Toc isoforms altered intracellular oxidative status in Caco-2 cells. Tetradecanoylphorbol Acetate NFE2 like bZIP transcription factor 2 Homo sapiens