Title : Hepatocyte heterogeneity in glutamate metabolism and bidirectional transport in perfused rat liver.

Pub. Date : 1989 Oct 20

PMID : 2572417






4 Functional Relationships(s)
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1 This was observed in both, antegrade and retrograde perfusions and suggests an almost exclusive uptake of glutamate into perivenous glutamine-synthetase-containing hepatocytes. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus
2 Comparison of the specific radioactivities of glutamine and glutamate released from perivenous cells indicates that about 60% of total glutamate release from the liver is derived from the perivenous glutamine-synthetase-containing cell population. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus
3 Comparison of the specific radioactivities of glutamine and glutamate released from perivenous cells indicates that about 60% of total glutamate release from the liver is derived from the perivenous glutamine-synthetase-containing cell population. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus
4 It is concluded that, in the intact liver, vascular glutamate is almost exclusively taken up by the small perivenous hepatocyte population containing glutamine synthetase. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus