Title : Sumoylation of HDAC2 promotes NF-κB-dependent gene expression.

Pub. Date : 2015 Mar 30

PMID : 25704882






2 Functional Relationships(s)
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1 Accordingly, inhibitors of NF-kappaB and of the NF-kappaB/p53-regulated anti-apoptotic protein survivin significantly sensitize colon carcinoma cells expressing wild-type HDAC2 to apoptosis induced by the genotoxin doxorubicin. Doxorubicin nuclear factor kappa B subunit 1 Homo sapiens
2 Accordingly, inhibitors of NF-kappaB and of the NF-kappaB/p53-regulated anti-apoptotic protein survivin significantly sensitize colon carcinoma cells expressing wild-type HDAC2 to apoptosis induced by the genotoxin doxorubicin. Doxorubicin nuclear factor kappa B subunit 1 Homo sapiens