Title : Therapeutic polo-like kinase 1 inhibition results in mitotic arrest and subsequent cell death of blasts in the bone marrow of AML patients and has similar effects in non-neoplastic cell lines.

Pub. Date : 2015 Apr

PMID : 25697066






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Small molecule inhibitors targeting PLK1, such as BI2536 or BI6727 (Volasertib) are a promising therapeutic approach in such malignancies. BI 2536 polo like kinase 1 Homo sapiens
2 Here, we show a loss of specifically localized PLK1 in AML blasts in vivo, accompanied by mitotic arrest with transition into apoptosis, in bone marrow biopsies of AML patients after treatment with BI2536. BI 2536 polo like kinase 1 Homo sapiens