Pub. Date : 2015 May 1
PMID : 25695641
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Wy14643, a selective PPARalpha agonist, significantly induced Igfbp-2 gene expression in primary cultured hepatocytes. | pirinixic acid | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | To explore the role of PPARalpha in IGF-1 signalling, we treated primary cultured hepatocytes with Wy14643 and observed a decrease in the number of IGF-1 receptors (IGF-1Rs) and in Akt phosphorylation. | pirinixic acid | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | These results suggest that PPARalpha controls IGF-1 signalling through the up-regulation of hepatic Igfbp-2 transcription during fasting and Wy14643 treatment. | pirinixic acid | peroxisome proliferator activated receptor alpha | Mus musculus |