Title : Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

Pub. Date : 2015 Mar 12

PMID : 25695162






1 Functional Relationships(s)
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Protein Name
Organism
1 Constitutively active mutant KRas displays a reduced rate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resulting in the perpetual activation of Ras pathways. Guanosine Triphosphate KRAS proto-oncogene, GTPase Homo sapiens