Pub. Date : 2015
PMID : 25692408
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition. | Lapatinib | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition. | Lapatinib | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Lapatinib resistance could be reversed by mTOR kinase inhibition. | Lapatinib | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | Further, treatment with the mTOR kinase inhibitor AZD8055 or the Hsp90 inhibitor 17-AAG reversed expression of IAPs and overcame lapatinib resistance in LapR cells. | Lapatinib | mechanistic target of rapamycin kinase | Homo sapiens |