Title : The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation.

Pub. Date : 2015 May

PMID : 25690686






1 Functional Relationships(s)
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1 Thus, our data suggest that clotrimazole inhibits melanin synthesis by promoting the proteasomal degradation of tyrosinase, which is mediated through activation of the ERK and Akt signaling pathways. Melanins tyrosinase Mus musculus