Title : Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability.

Pub. Date : 2015 Jun

PMID : 25687825






2 Functional Relationships(s)
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1 Supplementation of thiols in Nrf2(-/-) cocultures via addition of glutathione ester, N-acetylcysteine, beta-mercaptoethanol, or cysteine itself restored T cell proliferation as well as cytotoxicity by increasing intracellular GSH. Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens
2 Mechanistically, we identified two potential Nrf2-regulated genes involved in thiol synthesis in BMDMPhi: the cystine transporter subunit xCT and the modulatory subunit of the GSH-synthesizing enzyme gamma-GCS (GCLM). Sulfhydryl Compounds NFE2 like bZIP transcription factor 2 Homo sapiens