Title : Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells.

Pub. Date : 2015 May

PMID : 25683911






2 Functional Relationships(s)
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1 Treatment of p53 wild-type melanoma cells with the genotoxic agent doxorubicin induces G2-M arrest, inhibitory phosphorylation of cell cycle kinase Cdc2 (CDK1) and enhanced expression of p53/p21. Doxorubicin cyclin dependent kinase 1 Homo sapiens
2 Treatment of p53 wild-type melanoma cells with the genotoxic agent doxorubicin induces G2-M arrest, inhibitory phosphorylation of cell cycle kinase Cdc2 (CDK1) and enhanced expression of p53/p21. Doxorubicin cyclin dependent kinase 1 Homo sapiens