Title : Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis.

Pub. Date : 2015 Jan 30

PMID : 25682199






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis. Cisplatin CASP8 and FADD like apoptosis regulator Homo sapiens
2 These results establish a novel mechanism for potentiation of anticancer activity with the combination of Chal-24 and cisplatin: to enhance apoptosis signaling through Ripoptosome formation and to release the apoptosis brake through c-FLIPL degradation. Cisplatin CASP8 and FADD like apoptosis regulator Homo sapiens