Pub. Date : 2015 Mar 15
PMID : 25681332
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report that the eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes. | 15-deoxy-delta(12,14)-prostaglandin J2 | caspase 1 | Mus musculus |
| 2 | We report that the eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes. | 15-deoxy-delta(12,14)-prostaglandin J2 | caspase 1 | Mus musculus |
| 3 | Instead, 15d-PGJ2 prevents the autoproteolytic activation of caspase-1 and the maturation of IL-1beta through induction of a cellular state inhibitory to caspase-1 proteolytic function. | 15-deoxy-delta(12,14)-prostaglandin J2 | caspase 1 | Mus musculus |
| 4 | Instead, 15d-PGJ2 prevents the autoproteolytic activation of caspase-1 and the maturation of IL-1beta through induction of a cellular state inhibitory to caspase-1 proteolytic function. | 15-deoxy-delta(12,14)-prostaglandin J2 | caspase 1 | Mus musculus |