Title : Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis.

Pub. Date : 2015 Apr

PMID : 25680941






2 Functional Relationships(s)
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1 EAE mice treated with Fingolimod exhibited substantially elevated levels of Shh, its receptor Smoothened and effector Gli1 in the white matter of the CNS. Fingolimod Hydrochloride smoothened, frizzled class receptor Mus musculus
2 However, combination treatment of EAE mice with cyclopamine-Fingolimod decreased Fingolimod monotherapy elevated protein levels of Smoothened and Gli1, and abolished the effect of Fingolimod on OPC proliferation and differentiation, as well as on neurological function outcome. Fingolimod Hydrochloride smoothened, frizzled class receptor Mus musculus