| Protein Name | smoothened, frizzled class receptor |
|---|---|
| Organism | Mus musculus |
| Gene ID | 319757 |
| Gene Symbol | Smo |
| UniProt | P56726 (SMO_MOUSE), Q4VBD5 (Q4VBD5_MOUSE), Q8BJN8 (Q8BJN8_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
86
Total Number of Articles : 90 |
Description |
smoothened, frizzled class receptor |
| Gene Summary |
Enables oxysterol binding activity; protein kinase A catalytic subunit binding activity; and protein sequestering activity. Involved in several processes, including regionalization; regulation of animal organ morphogenesis; and regulation of macromolecule metabolic process. Acts upstream of or within several processes, including nervous system development; positive regulation of cell population proliferation; and regionalization. Located in several cellular components, including centriole; ciliary membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; genitourinary system; and skeleton. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; malignant pleural mesothelioma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human SMO (smoothened, frizzled class receptor). [provided by Alliance of Genome Resources, Jul 2025] |
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