Title : Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral T-cell lymphomas: pathogenetic implications and therapeutic options.

Pub. Date : 2014

PMID : 25674239






1 Functional Relationships(s)
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1 Agents that may be considered based on existing data include: bortezomib to inhibit NF-kappaB pathway activation; metformin to inhibit both NF-kappaB and mTORC2 and histone deacteylase inhibitors to inhibit mTORC2 pathway signaling. Metformin nuclear factor kappa B subunit 1 Homo sapiens