Title : Resveratrol alters human endothelial cells redox state and causes mitochondrial-dependent cell death.

Pub. Date : 2015 Apr

PMID : 25656643






2 Functional Relationships(s)
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1 The specific cytochrome P450 (CYP) 2C9 inhibitor, sulfaphenazole, counteracted both oxidative stress and mitochondrial membrane depolarization, providing EC protection against resveratrol-elicited pro-oxidant effects. Resveratrol cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 Our findings strongly suggest that CYP2C9 mediates resveratrol-induced oxidative stress leading to mitochondria impairment and EC death. Resveratrol cytochrome P450 family 2 subfamily C member 9 Homo sapiens