Title : Astrocytic pathology of methionine sulfoximine-induced encephalopathy.

Pub. Date : 1989

PMID : 2565645






2 Functional Relationships(s)
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1 To investigate the roles imposed on astrocytes for glutamate metabolism, a specific inhibitor of glutamine synthetase (GS), methionine sulfoximine (MSO), was repeatedly administered to rats and histopathological changes were correlated with glycogen accumulation and the immunocytochemistry of GS and glial fibrillary acidic protein (GFAP). Methionine Sulfoximine glutamate-ammonia ligase Rattus norvegicus
2 To investigate the roles imposed on astrocytes for glutamate metabolism, a specific inhibitor of glutamine synthetase (GS), methionine sulfoximine (MSO), was repeatedly administered to rats and histopathological changes were correlated with glycogen accumulation and the immunocytochemistry of GS and glial fibrillary acidic protein (GFAP). Methionine Sulfoximine glutamate-ammonia ligase Rattus norvegicus