Title : A store-operated calcium channel inhibitor attenuates collagen-induced arthritis.

Pub. Date : 2015 Jun

PMID : 25651822






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Similarly, treatment with YM-58483 after the onset of CIA: (i) reversed the clinical scores; (ii) reduced paw oedema; (iii) attenuated mechanical and thermal hypersensitivity; (iv) improved spontaneous motor activity; (v) decreased periphery production of IL-1beta, IL-6 and TNF-alpha; and (vi) reduced spinal activation of ERK and calmodulin-dependent PKII (CaMKIIalpha). 4-methyl-4'-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)-1,2,3-thiadiazole-5-carboxanilide tumor necrosis factor Mus musculus