Pub. Date : 2015 Feb 3
PMID : 25651183
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency. | Iron | aconitase 1 | Mus musculus |
| 2 | Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool. | Iron | aconitase 1 | Mus musculus |
| 3 | Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool. | Iron | aconitase 1 | Mus musculus |
| 4 | Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool. | Iron | aconitase 1 | Mus musculus |
| 5 | Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool. | Iron | aconitase 1 | Mus musculus |
| 6 | Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool. | Iron | aconitase 1 | Mus musculus |
| 7 | Surprisingly, our data indicate that IRP1 activation sustains mitochondrial iron supply and function rather than driving detrimental iron overload. | Iron | aconitase 1 | Mus musculus |
| 8 | Our results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism. | Iron | aconitase 1 | Mus musculus |