PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25651183-0	2015	Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency.	Iron	49-53	aconitase 1	Mus musculus	0-25	
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	85-89	aconitase 1	Mus musculus	112-116	
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	85-89	aconitase 1	Mus musculus	177-181	
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	147-151	aconitase 1	Mus musculus	85-110	
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	147-151	aconitase 1	Mus musculus	112-116	
25651183-3	2015	Using a mouse model of hepatic FXN deficiency in combination with mice deficient for iron regulatory protein 1 (IRP1), a key regulator of cellular iron metabolism, we show that IRP1 activation in conditions of Fe-S deficiency increases the available cytosolic labile iron pool.	Iron	147-151	aconitase 1	Mus musculus	177-181	
25651183-4	2015	Surprisingly, our data indicate that IRP1 activation sustains mitochondrial iron supply and function rather than driving detrimental iron overload.	Iron	76-80	aconitase 1	Mus musculus	37-41	
25651183-6	2015	Our results uncover an unexpected protective role of IRP1 in pathological conditions associated with altered Fe-S metabolism.	Iron	109-113	aconitase 1	Mus musculus	53-57