Pub. Date : 2014 Dec
PMID : 25642443
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: HER2-positive breast cancer sensitivity to anthracyclines is enhanced when topoisomerase IIalpha (TOP2A) is co-amplified under both adjuvant and metastatic settings. | Anthracyclines | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 2 | However, the relationship between anthracycline sensitivity and TOP2A amplification in HER2-positive breast cancers in neoadjuvant settings is not known. | Anthracyclines | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |
| 3 | Thus, the HER2/TOP2A co-amplified subtype may be effectively treated by anthracycline-containing regimens alone. | Anthracyclines | erb-b2 receptor tyrosine kinase 2 | Homo sapiens |