Pub. Date : 2015 Mar
PMID : 25630653
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Atorvastatin protects cardiomyocytes from oxidative stress by inhibiting LOX-1 expression and cardiomyocyte apoptosis. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Homo sapiens |
| 2 | In this study, we examined whether atorvastatin inhibits H2O2-induced LOX-1 expression and H9c2 cardiomyocyte apoptosis, and investigated the underlying signaling pathway. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Homo sapiens |
| 3 | H2O2-induced LOX-1 expression, caspase protein expression, and cardiomyocyte apoptosis were attenuated by pretreatment with atorvastatin. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Homo sapiens |
| 4 | These findings indicate that atorvastatin protects cardiomyocyte from oxidative stress via inhibition of LOX-1 expression and apoptosis, and that activation of H2O2-inhibited phosphorylation of Akt may play an important role in the protective function of atorvastatin. | Atorvastatin | oxidized low density lipoprotein receptor 1 | Homo sapiens |