Title : Structure-based grafting and identification of kinase-inhibitors to target mTOR signaling pathway as potential therapeutics for glioblastoma.

Pub. Date : 2015 Feb

PMID : 25625417






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1 In particular, few sophisticated kinase-inhibitors as well as a flavonoid myricetin showed high inhibitory activities, which could thus be considered as potential lead compounds to develop new potent, selective mTOR-inhibitors. Flavonoids mechanistic target of rapamycin kinase Homo sapiens