Title : ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling.

Pub. Date : 2015 Feb

PMID : 25614670






5 Functional Relationships(s)
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1 Our laboratory and others have shown that adipose triglyceride lipase (ATGL) increases the activity of the nuclear receptor PPAR-alpha, a PGC-1alpha binding partner, to promote fatty acid oxidation. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
2 Fatty acids bind and activate PPAR-alpha; therefore, it has been presumed that fatty acids derived from ATGL-catalyzed lipolysis act as PPAR-alpha ligands. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
3 Fatty acids bind and activate PPAR-alpha; therefore, it has been presumed that fatty acids derived from ATGL-catalyzed lipolysis act as PPAR-alpha ligands. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
4 Fatty acids bind and activate PPAR-alpha; therefore, it has been presumed that fatty acids derived from ATGL-catalyzed lipolysis act as PPAR-alpha ligands. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens
5 Fatty acids bind and activate PPAR-alpha; therefore, it has been presumed that fatty acids derived from ATGL-catalyzed lipolysis act as PPAR-alpha ligands. Fatty Acids peroxisome proliferator activated receptor alpha Homo sapiens