Pub. Date : 2015 Feb 15
PMID : 25614335
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclophilin D-mediated apoptosis attributes to sorafenib-induced cytotoxicity in clear cell-renal cell carcinoma. | Sorafenib | peptidylprolyl isomerase F | Homo sapiens |
| 2 | The aim of this study was to assess the effects of the multi-target drug, sorafenib, on clear cell-renal cell carcinoma (ccRCC) necrosis by regulating CypD expression and to explore whether this effect was related to the phosphorylation of extracellular signal-regulated kinases (ERKs). | Sorafenib | peptidylprolyl isomerase F | Homo sapiens |
| 3 | Sorafenib induced the apoptosis of 786-O cells, which was coupled with the upregulation of CypD. | Sorafenib | peptidylprolyl isomerase F | Homo sapiens |
| 4 | Cyclosporin A (CsA, the inhibitor of CypD) and CypD siRNA inhibited the effect of sorafenib on apoptosis-induced 786-O and mitochondrial membrane potential depolarization. | Sorafenib | peptidylprolyl isomerase F | Homo sapiens |
| 5 | Epidermal growth factor (EGF, the activator of ERK) and ERK overexpression inhibited the effect of sorafenib on CypD expression, apoptosis-induced 786-O and mitochondrial membrane potential depolarization. | Sorafenib | peptidylprolyl isomerase F | Homo sapiens |
| 6 | Sorafenib induced apoptosis in ccRCC through CypD upregulation and this effect was related to the inhibition of p-ERK. | Sorafenib | peptidylprolyl isomerase F | Homo sapiens |