Title : Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription.

Pub. Date : 2015 Mar

PMID : 25609572






1 Functional Relationships(s)
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1 We have previously demonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation leads to chromosome breakage at replication forks initiated from virtually all origins after transient exposure to hydroxyurea (HU), an inhibitor of ribonucleotide reductase. Hydroxyurea protein kinase MEC1 Saccharomyces cerevisiae S288C