Title : Development of gold nanoparticle based colorimetric method for quantitatively studying the inhibitors of Cu(2+)/Zn(2+) induced β-amyloid peptide assembly.

Pub. Date : 2015 Feb 9

PMID : 25597800






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1 In this paper, a kind of gold nanoparticle (GNP)-based colorimetric assay has been developed for studying the reversible interaction of beta-amyloid peptide (Abeta) with Cu(2+) and Zn(2+), and quantitatively analyzing four inhibitors (i.e., EDTA, EGTA, histidine and clioquinol) of Cu(2+)/Zn(2+) induced Abeta assembly. Histidine amyloid beta precursor protein Homo sapiens