Pub. Date : 2015 Mar 12
PMID : 25595736
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we showed that induction of PF4/heparin-specific antibodies by PF4/heparin complexes was markedly impaired in mice depleted of CD4 T cells by anti-CD4 antibodies. | Heparin | platelet factor 4 | Mus musculus |
| 2 | Here, we showed that induction of PF4/heparin-specific antibodies by PF4/heparin complexes was markedly impaired in mice depleted of CD4 T cells by anti-CD4 antibodies. | Heparin | platelet factor 4 | Mus musculus |
| 3 | Furthermore, Rag1-deficient recipient mice produced PF4/heparin-specific antibodies upon PF4/heparin challenge when reconstituted with a mixture of wild-type splenic B cells and splenocytes from B-cell-deficient (muMT) mice but not splenocytes from T- and B-cell-deficient (Rag1 knockout) mice. | Heparin | platelet factor 4 | Mus musculus |
| 4 | Furthermore, Rag1-deficient recipient mice produced PF4/heparin-specific antibodies upon PF4/heparin challenge when reconstituted with a mixture of wild-type splenic B cells and splenocytes from B-cell-deficient (muMT) mice but not splenocytes from T- and B-cell-deficient (Rag1 knockout) mice. | Heparin | platelet factor 4 | Mus musculus |
| 5 | Lastly, mice with B cells lacking CD40, a B-cell costimulatory molecule that helps T-cell-dependent B-cell responses, displayed a marked reduction of PF4/heparin-specific antibody production following PF4/heparin challenge. | Heparin | platelet factor 4 | Mus musculus |