Title : Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension.

Pub. Date : 2015 Mar 5

PMID : 25595485






2 Functional Relationships(s)
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1 AngII-induced vasoconstriction was augmented by inhibition of diacylglycerol lipase (tetrahydrolipstatin) and was attenuated by inhibition of monoacylglycerol lipase (JZL184) suggesting a functionally relevant role for endogenously produced 2-AG. Orlistat angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus
2 In VSMCs, AngII-stimulated 2-AG-formation was inhibited by tetrahydrolipstatin and potentiated by JZL184. Orlistat angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus