Title : Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization.

Pub. Date : 2014

PMID : 25593505






3 Functional Relationships(s)
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1 PURPOSE: The inhibition of GSK-3beta blocks mitochondrial membrane permeability transition (mMPT) for HLE-B3 cells in atmospheric oxygen. Oxygen glycogen synthase kinase 3 beta Homo sapiens
2 RESULTS: Cultured lens epithelial cells maintained in hypoxia (1% oxygen) and subsequently reintroduced into atmospheric oxygen and treated with the GSK-3beta inhibitor SB216763 illustrated a marked inhibition of phosphorylation of glycogen synthase (downstream substrate of GSK-3beta) and significant increase in nuclear translocation of beta-catenin. Oxygen glycogen synthase kinase 3 beta Homo sapiens
3 RESULTS: Cultured lens epithelial cells maintained in hypoxia (1% oxygen) and subsequently reintroduced into atmospheric oxygen and treated with the GSK-3beta inhibitor SB216763 illustrated a marked inhibition of phosphorylation of glycogen synthase (downstream substrate of GSK-3beta) and significant increase in nuclear translocation of beta-catenin. Oxygen glycogen synthase kinase 3 beta Homo sapiens