Title : Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

Pub. Date : 2015 Jan 15

PMID : 25590800






1 Functional Relationships(s)
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1 A-1210477 induces the hallmarks of intrinsic apoptosis and demonstrates single agent killing of multiple myeloma and non-small cell lung cancer cell lines demonstrated to be MCL-1 dependent by BH3 profiling or siRNA rescue experiments. A-1210477 MCL1 apoptosis regulator, BCL2 family member Homo sapiens