Pub. Date : 2014 Dec 30
PMID : 25587029
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To address the significance of p27 mislocalization in Her2+ breast cancer cells we interrogated the cellular response to the dual-Her2/EGFR kinase inhibitor, lapatinib. | Lapatinib | interferon alpha inducible protein 27 | Homo sapiens |
| 2 | Knockdown of p27 using shRNA sensitized Her2+ cells to lapatinib-induced apoptosis. | Lapatinib | interferon alpha inducible protein 27 | Homo sapiens |
| 3 | Moreover, expression of a constitutively cytoplasmic form of p27 (p27DeltaNLS) reversed the lapatinib-induced apoptosis, suggesting that cytoplasmic p27 contributed to lapatinib resistance in Her2+ breast cancer cells by suppressing apoptosis. | Lapatinib | interferon alpha inducible protein 27 | Homo sapiens |
| 4 | Moreover, expression of a constitutively cytoplasmic form of p27 (p27DeltaNLS) reversed the lapatinib-induced apoptosis, suggesting that cytoplasmic p27 contributed to lapatinib resistance in Her2+ breast cancer cells by suppressing apoptosis. | Lapatinib | interferon alpha inducible protein 27 | Homo sapiens |
| 5 | Moreover, expression of a constitutively cytoplasmic form of p27 (p27DeltaNLS) reversed the lapatinib-induced apoptosis, suggesting that cytoplasmic p27 contributed to lapatinib resistance in Her2+ breast cancer cells by suppressing apoptosis. | Lapatinib | interferon alpha inducible protein 27 | Homo sapiens |
| 6 | Moreover, expression of a constitutively cytoplasmic form of p27 (p27DeltaNLS) reversed the lapatinib-induced apoptosis, suggesting that cytoplasmic p27 contributed to lapatinib resistance in Her2+ breast cancer cells by suppressing apoptosis. | Lapatinib | interferon alpha inducible protein 27 | Homo sapiens |