Title : Effect of orexin A on apoptosis in BGC-823 gastric cancer cells via OX1R through the AKT signaling pathway.

Pub. Date : 2015 May

PMID : 25586545






2 Functional Relationships(s)
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1 In addition, BGC-823 cells were treated with AKT inhibitor PF-04691502 or OX1R-specific antagonist SB334867 in combination with orexin A, in order to examine the activation of AKT and caspase-3. 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea hypocretin receptor 1 Homo sapiens
2 The OX1R antagonist SB334867 (10-6 M) and AKT antagonist PF-04691502 (10-6 M), when used individually or in combination, abolished the effect of orexin A (10-8 M) on BGC-823 cells. 1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea hypocretin receptor 1 Homo sapiens