Pub. Date : 2015 Feb 15
PMID : 25582706
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyp7a1, the rate-limiting enzyme in BA synthesis, was decreased more by CA and DCA than CDCA and LCA. | dichloroacetylene | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Thus in conclusion, CA and DCA are more potent FXR activators than CDCA and LCA when fed to mice, and thus they are more effective in decreasing the expression of the rate limiting gene in BA synthesis Cyp7a1 and the 12-hydroxylation of BAs Cyp8b1, and are also more effective in increasing the expression of Abcg5/Abcg8, which is responsible for biliary cholesterol excretion. | dichloroacetylene | cytochrome P450, family 7, subfamily a, polypeptide 1 | Mus musculus |