Title : Protective effect of δ-amyrone against ethanol-induced gastric ulcer in mice.

Pub. Date : 2015 Jun

PMID : 25572867






3 Functional Relationships(s)
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1 Analysis of cytokines in gastric tissue and serum of ethanol-induced mice showed the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were decreased by delta-amyrone in response to NF-kappaB p65. amyrone interleukin 6 Mus musculus
2 Analysis of cytokines in gastric tissue and serum of ethanol-induced mice showed the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were decreased by delta-amyrone in response to NF-kappaB p65. amyrone interleukin 6 Mus musculus
3 These results suggested that delta-amyrone exerts its protective effect on experimental gastric ulcer by inhibiting NF-kappaB signaling pathways, which subsequently reduces overproduction of the inducible enzymes iNOS and suppresses the release of the inflammatory factors TNF-alpha, IL-6 and NO. amyrone interleukin 6 Mus musculus