Title : MAPK inhibitors differently modulate TGF-β/Smad signaling in HepG2 cells.

Pub. Date : 2015 May

PMID : 25560488






1 Functional Relationships(s)
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1 After DEN-induced hepatocellular carcinoma (HCC) in rats showed increased phosphorylation of JNK1/2, p38, and ERK1/2, we next antagonized TGF-beta1-induced phosphorylation of JNK1/2, p38, ERK1/2, Smad2/3 signaling in HepG2 cells using SP600125, SB203580, and PD98059, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one transforming growth factor, beta 1 Rattus norvegicus