Title : Exploring the mechanisms of the reductase activity of neuroglobin by site-directed mutagenesis of the heme distal pocket.

Pub. Date : 2015 Jan 27

PMID : 25554946






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Neuroglobin (Ngb) is a six-coordinate globin that can catalyze the reduction of nitrite to nitric oxide. Nitrites neuroglobin Homo sapiens
2 Neuroglobin (Ngb) is a six-coordinate globin that can catalyze the reduction of nitrite to nitric oxide. Nitrites neuroglobin Homo sapiens
3 We have shown that the H64L Ngb mutation increases the rate of nitrite reduction by 2000-fold compared to that of wild-type Ngb [Tiso, M., et al. Nitrites neuroglobin Homo sapiens
4 This suggests a relationship between the nitrite reduction rate and heme accessibility in Ngb, particularly marked for His64(E7) mutants. Nitrites neuroglobin Homo sapiens