Title : Down-regulation of protein kinase C potentiates angiotensin II-stimulated polyphosphoinositide hydrolysis in vascular smooth-muscle cells.

Pub. Date : 1989 Aug 15

PMID : 2554890






3 Functional Relationships(s)
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1 Short-term (10 min) pretreatment of SMC with 12-O-tetradecanoylphorbol 13-acetate (TPA; 100 nM) decreases the angiotensin II-induced InsP3 formation. Tetradecanoylphorbol Acetate angiotensinogen Rattus norvegicus
2 Short-term (10 min) pretreatment of SMC with 12-O-tetradecanoylphorbol 13-acetate (TPA; 100 nM) decreases the angiotensin II-induced InsP3 formation. Tetradecanoylphorbol Acetate angiotensinogen Rattus norvegicus
3 In parallel with this potentiation of angiotensin II-induced generation of InsP3 by TPA, a down-regulation of protein kinase C activity is observed. Tetradecanoylphorbol Acetate angiotensinogen Rattus norvegicus